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Autonomous growth in serum-free media, as non-adherent neurospheres, is thought to be a surrogate marker of neural and malignant progenitors [9], [14], [15], [16], [17], [18].
Autonomous growth with clonal B-cell expansion and selection mediated by chronic antigen stimulation have been hypothesized to contribute to the development of MM.
This study was designed to delineate the mechanisms by which ΔβC increases the frequency to autonomous growth.
They can also be induced to express cytokines that promote their autonomous growth, further supporting their in vivo expansion.
In cancer, the deregulation of growth signaling pathways drives changes in the cell's architecture and its environment that allow autonomous growth of tumors.
Evolution of DANN architecture includes stage of autonomous growth of subnets developed by separate Cognitive Sensors and stage of cooperative growth of resulting network.
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We have sought to identify pathways that mediate the cell-autonomous growth suppressor activity of the Drosophila endocytic gene ept, which encodes a homolog of mammalian Tumor Susceptibility Gene-101.
Because MEK1T55delinsRT suppresses cell-autonomous growth, the existence in a population of cells before treatment is unexpected.
Blasts from 19 out of 31 cells which expressed PAb240 co-expressed PAb1620, expression of PAb1620 was associated with non-autonomous growth in vitro.
The unraveling of the mechanisms governing the alternative mitochondria-independent, AMPK-activating effects of metformin leading to cancer cell-autonomous growth inhibitory effects has just been initiated.
This non-autonomous growth reduction is not restricted to the local neighbors in a cell cell contact-dependent manner, but rather affects all tissues of the organism.
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