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For this reason, the study was judged to be at unclear risk of reporting bias.
No study explicitly reported blinding of outcome assessors and so all were assessed to be at unclear risk of detection bias.
Five were assessed to be at low risk of selection bias [25, 26, 28, 29, 31, 33, 34] and the remaining study was at unclear risk [27].
Due to poor reporting, many were rated at unclear risk of bias, and missing data were observed in a number of trials.
MISAO has been evaluated in four trials which were judged to be at unclear risk of bias; this could have potentially confused the results.
We judged all five studies to be at unclear risk for selection bias related to allocation since they did not adequately describe the method of allocation concealment [36, 37, 38, 39, 40].
Consequently, most information in this review is from studies rated at unclear risk of bias, and the proportion of studies at high risk of bias for missing outcome data needs to be considered when interpreting the results (Additional file 1: Figures S5a and S5b).
Ninety-three trials (87%) were at high risk of bias and 14 (13%) at unclear risk of bias.
All trials were at unclear to high risk of bias.
We judged 67 of 72 studies to be at unclear risk of bias in this domain.
The remaining six trials were at unclear risk due to inadequate descriptions of allocation concealment.
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