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The mitochondrial ultrastructure at the cristae level is thus modified.
Next, Guarani et al. conducted a series of experiments to determine what role QIL1 plays at the cristae junctions.
While both long insoluble and short soluble forms of OPA1 are found at the cristae junctions, it is the short form that is reported to be anti-apoptotic.
(2015) demonstrate that a MICOS core subunit, Mic10, is crucial for mitochondrial cristae formation by forming oligomers at the cristae junctions.
(2015) give mechanistic insights into cristae formation and show that Mic10 plays a central role in forming the inner-membrane curvature at the cristae junctions.
In addition, UCP4 is the only UCP whose ion transport activities were unaffected by CL, a mitochondria-specific lipid that is localized at the cristae membrane of the IMM [ 11].
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The rather voluminous braincase ends distally at the crista nuchalis.
The same is true for the structure of the MICOS complex at the crista junctions.
Formation of cristae depends both on the rows of ATP synthase dimers along the edges [ 30] and on the MICOS complex at the crista junctions [ 32].
They are disk-like lamellar, tubular or bag-like extensions of the inner boundary membrane, and are continuous with it at the crista junctions.
It is thought that the MICOS complex forms a diffusion barrier within the inner membrane at the crista junctions to account for the apparent lateral segregation of proteins between the cristae and boundary membranes.
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