At fragile sites, replication forks have to cover unusually long distances.
These results suggest that chromosome fragility, particularly at fragile sites, may contribute to the generation of fusion transcripts in cancer cells.
Here, the current view of the origin of CFS fragility will be discussed in the light of studies indicating that instability at fragile sites may be the end result of problems encountered during DNA replication.
You can feel the constant fear of violence wearing away at fragile minds, and the material deprivation wearing away at bodies that have often been damaged even before they arrive at the camp.
Dealing with pressures from outside its borders should be Floyd Bennett's next priority, say environmentalists, who worry that waves from motorboats on Jamaica Bay are chipping away at fragile wetland edges.
Just as a sculptor feeds his passion by constructing new statues or a carpenter by chipping away at fragile antiques to restore them to their beauty, so I fed my sense of worth by fixing what was in my control.
Consequently, replicating primary cells steadily accrue macroH2A1.2 at fragile regions, whereas macroH2A1.2 loss in these cells triggers DNA damage signaling-dependent senescence, a hallmark of RS.
The RSC nucleosome remodeler acts through the motifs to establish stable +1 and −1 nucleosome positions, while binding of a small set of general regulatory (pioneer) factors at fragile nucleosome promoters plays a key role in their destabilization.
We infer that magma intruded into the obtained dike, where rapid opening resulted in an accumulation of strain in the surrounding rocks, and the VT earthquakes were generated at fragile places beneath Minami-dake and around the usual eruptive conduit to release the accumulated strain.
Gaps and constrictions at fragile sites were analyzed using a Nikon fluorescent microscope.
It is known that most chromosomal gaps and constrictions following aphidicolin treatment occur at fragile sites [26].
