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Notably, while SQ AT expansion is associated with diminished risk, expansion of visceral AT is associated with increased risk of metabolic disease [ 15].
The marked upregulation of IGFBP5 seen in AT from pregnant women supports a similar role for the IGF-1 signalling pathway in adult AT expansion.
The concurrent expression of IGFBP5 in AT and secretion of PAPP-A by the placenta suggests a mechanism whereby the local concentration of IGF-1 increasedsed in AT through interaction with IGFBP5 and release in response to PAPP-A secretion, thereby coordinating placental function with maternal AT expansion (Fig. 4).
Obese individuals are at increased risk of developing cardiovascular disease (CVD), a consequence of adipose tissue (AT) expansion and subsequent dysfunction [ 1, 2].
The fact that not all AT expansion is necessarily associated with pathological changes makes us rethink our understanding towards obesity.
NR undoubtedly represents the most efficient strategy reducing visceral AT, suggesting an inverse relationship between AT expansion and lifespan.
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In addition, we do not know the proper utility weights, and when looking at expansions and recessions, we know for a fact that (pi ) is not 1/2.
Bodies receive needle-inked adornments at skin-art parlors; minds seek enlightenment, or at least expansion, at many meditation clinics.
The commission will also look at possible expansion at two other major London airports - Gatwick and Stansted.
A young Rupert Murdoch was great at managing expansion.
"We're still looking at an expansion, albeit a lot smaller.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com