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Four authors (TH, AT, ER and OW) developed a proposal for grouping of questions in domains.
TH, AT, ER, ASV and OW designed the study, performed the main analyses and drafted the discussion.
At ER presentation, written information on the current research will be provided to all parents.
Variations of attendances at ER by time of the day and weekday may reveal peaks and lows of the alcohol-related clinical burden at ER indicating special need for personnel and other resources.
In general, it is hypothesized that mechanosensitive channels at the plasma membrane can potentially mediate the force-induced calcium release at ER by modulating force transmission efficiency, mechanically altering IP3R at ER through physical coupling, as well as affecting IP3R functions at ER.
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Similar(11)
ER stores are refilled through sustained Ca2+ influx at ER-plasma membrane (PM) membrane contact sites (MCSs).
Several E-Syts (extended synaptotagmin-like proteins) have been confirmed to act as tethers at ER-PM MCSs (Min et al., 2007; Giordano et al., 2013).
Unknown is the mechanism triggering INF2-mediated actin polymerization at ER-mitochondria intersections.
Similarly, high [Ca2+] microdomains at ER-mitochondria MCS drive excitation-metabolism coupling.
Notably, cells overexpressing Spire1C mWH2 displayed significantly fewer mitochondrial constrictions at ER-mitochondria intersections.
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