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This article reviews the performance characteristics of the currently available assays, and their usefulness for monitoring the use of AT concentrates in intensive care units, disseminated intravascular coagulation or severe infections, to restore the anticoagulant protective effect of heparin by supplementing the requested AT concentration.
Consequently, AT concentrates may have value in the treatment of sepsis-induced DIC.
Thus, supplementation with AT concentrates has been considered a rational therapy [ 4].
As shown in Figure 3, the survival curve for filters in patients supplemented or not with AT concentrates differed significantly between periods.
Open-labeled and phase II trials showed that administration of AT concentrates may improve the outcome of sepsis due to the reduction of hypercoagulability and due to the anti-inflammatory properties of AT [ 8- 10].
However, the reduced downtime in treated patients contributed to an enhancement in the daily dose of hemofiltration in patients who received AT concentrates, as assessed by the ratio of delivered to prescribed ultrafiltration.
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