In addition, our data show that the frequency of OC is high (31.05%) at CMF, which agrees with a previous report of 30.0% by Kadarmideen et al. [ 12].
Other articles in the series can be found online at CMF, cyclophosphamide, methotrexate and 5-fluorouracil; ER, oestrogen receptor; FAC, 5-fluorouracil, doxorubicin and cyclophosphamide; FEC, 5-fluorouracil, epirubicin and cyclophosphamide; OS, ovarian suppression; XRT, radiotherapy.
It was noted in that study that there was a strong tendency for the older patients to be undertreated, and in a subsequent study from the same group, looking at alternating CMF and adriamycin, it is clear that older women had a poorer outcome than younger women on the same regimen (Bonadonna et al, 1995b).
Kaplan Meier estimates of DFS at 5 years were 0.51 for CMF, 0.56 for CMF → GT, 0.53 for A → CMF and 0.71 for A → CMF → GT.
The DD-schedule group received treatment with four cycles of epirubicin and paclitaxel at 14-day intervals, followed by three cycles of CMF at 14-day intervals.
The CS group received a conventional sequential regimen: four cycles of epirubicin and cyclophosphamide at 21-day intervals followed by three cycles of CMF at 21-day intervals.
Preheated 2 × hybridization buffer (50% formamide, 10 × SSC, 0.01% SDS) was added just before hybridization at 42°C o/n onto the Human Genome Oligo Set Version 3.0 arrays, manufactured at the Central Microarray Facility (CMF) of the Netherlands Cancer Institute.
Preheated hybridization buffer (25% formamide, 5 × SSC, 0.1% SDS) was added just before overnight hybridization at 42°C to human 35 K oligo microarrays, manufactured at the Central Microarray Facility (CMF) of the Netherlands Cancer Institute.
Preheated hybridization buffer (25% formamide, 5× SSC, 0.1% SDS) was added just before hybridization at 42°C o/n in to human 18K cDNA microarrays slides, manufactured at the Central Microarray Facility (CMF) of the Netherlands Cancer Institute.
The estimated OS at 5 years were 83% for A → CMF vs 79% for CMF.
In assessing the unit's achievements, while only 0.24 per cent of the population of Brisbane belonged to the CMF at the time, the PNGVR had succeeded in recruiting 2.14 percent of the white population of the territories.
