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Recruitment of the protein lysine methyltransferase DOT1L at aberrant loci is a frequent mechanism driving acute lymphoid and myeloid leukemias, particularly in infants, and pharmacological inhibition of DOT1L extends survival in a mouse model of mixed lineage leukemia.
Although the cryptic pointers at aberrant junctions are often longer than the non-scrambled pointers they replace (Table S2), they are generally in the same length range as scrambled pointers and usually not longer than the original, displaced scrambled pointer.
Candidate mutations were scored at sub-genic resolution and unambiguously reveal structural details at aberrant loci.
miR-29 is another miRNA that is often expressed at aberrant levels in cancers, including CLL, hepatocellular carcinoma, and breast cancer [ 105- 107].
At times, the papilla of Vater can terminate at aberrant sites, including the stomach, pyloric canal, duodenal bulb, and the third or fourth portion of the duodenum.
However, no evidence of linked haplotypes at aberrant sites between neighbouring genes or on very small scales between exons within the same gene was detected (Table 5).
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Yet a few pages later, he describes the indulgences at RKO as aberrant, and concedes that had he shot nothing else in his life but the footage of fishermen in Brazil, the surviving fragments would have marked him out as a supreme artist in film.
"The Viacom people found some of the stuff that went on at MTV aberrant.
Now involved in producing and business ventures (including the recent purchase of Miramax Studios from Disney), he looks back at the aberrant highs of his heartthrob days, the changing nature of stardom in Hollywood, the trade-off he has made between high life and home life, and the step-by-step effort behind his show business survival.
We compare the dN/dS rate at these aberrant sites with that observed between species and breeds of bovid.
Thus, a high frequency of poorly differentiated tumours showing both LOH at, and aberrant expression of, TP53 can be explained mechanistically.
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Justyna Jupowicz-Kozak
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