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Therefore, while competing σ ligands showed high binding affinity in the in vitro assay system, their pharmacokinetics may not be able to reach a sufficiently high concentration, or at a sufficient time, at the binding sites in solid tumours to exert their competing effects in our in vivo biodistribution study.
The bolus only technique assumes that at a sufficient time after a single-contrast bolus, a dynamic equilibrium exists [56] allowing the equivalent ECV measurement.
In simulations where the transpositional burst occurred at a sufficient time in the past, very few insertions will have accumulated zero substitutions.
Animals might counteract this problem with predictive coding, using foraging strategies that maximize information about the food source location at a sufficient time in the future (Polani, 2009; Tishby and Polani, 2011; Bialek, 2013).
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The carrier essentially allows the impregnated growth factor to release at a desirable rate and concentration, and to linger at injury sites for a sufficient time to recruit progenitors and stimulate tissue healing processes.
The obtained suspension was stirred at ambient temperature for a sufficient time (24 48 hrs).
The reaction mixture was vigorously shaken and allowed to react at room temperature for a sufficient time to complete the reaction.
The confidence and knowledge questions were repeated at the AT and FU time points and the help giving behaviour questions were repeated at FU (to provide staff a sufficient time period to demonstrate the effects of the training on actual practice).
In our earlier work we have shown that it is possible to reoxidize the STO substrate reduced during growth by annealing after deposition for a sufficient time at growth conditions for pressures ≥10−4 mbar (Fig. 3(b))21.
Its success is therefore empirically associated with effective delivery of potent therapeutics to the target site at a therapeutic concentration, for a sufficient time, and in a biologically active form.
For a study with excessive premature death of animals from incidental or chemical-related causes other than tumors at the organ site of interest, animals that died early may not have been alive long enough to contribute a sufficient time at risk to that study (Melnick et al. 2008; U.S. EPA 2005a).
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