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It is well recognized that phosphorylation of different Cx43 residues in the C-terminal leads to distinguishable changes in Cx43 properties including GJ gating, Cx43 assembly, trafficking, and degradation [ 1, 13- 15, 37].
AMPARs, localized at post-synaptic densities, are regulated by transmembrane auxiliary subunits that modulate AMPAR assembly, trafficking, gating, and pharmacology.
Furthermore, AMPAR assembly, trafficking, and functional heterogeneity depends on a large repertoire of auxiliary subunits a feature that is particularly striking for this type of iGluR.
Ubiquitin ligases function in the ubiquitin-proteasome complex, which regulates protein assembly, trafficking and degradation, a cellular activity itself regulated by nicotine [86].
Surfactant homeostasis is maintained by a balance among multi-tiered processes, including the synthesis assembly, trafficking, storage, secretion recycling and degradation of surfactant proteins and lipids.
Proper assembly, trafficking and targeting of the sarcoglycan complex is of vital importance, and mutations that severely perturb tetramer formation and localisation result in sarcoglycanopathy.
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Previous reports suggest that ER stress induction may alter APP trafficking [7], [8].
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