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As TRAIL resistance is a major preclusion to its clinical use, we envisaged a novel high-throughput screen (HTS) to identify sensitizing agents.
As TRAIL is a potentially important cancer therapeutic, many laboratories have attempted to find sensitizing agents utilizing a wide range of chemical libraries against various different cell types.
As TRAIL is increased with obesity, we wonder whether blocking TRAIL signaling would also prevent the development of insulin resistance.
As TRAIL in vivo is mainly protective in relation to cardiovascular effects, this makes the above interpretation into question.
As TRAIL induces apoptosis in normal human hepatocytes, the LO2 cells were also treated as a control group.
As TRAIL is considered a possible biologic antitumor agent, these two cytokines should be analyzed in larger-scale studies.
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Other TRAIL receptors such as TRAIL-R3 and TRAIL-R4 [ 4] act as decoy receptors that are able to inhibit the cytotoxic effects of TRAIL.
He is extremely keen to use Scotland as trail-blazer for the pure residence charge," reported Letwin.
Other strategies have involved assessing the ability of known anti-cancer agents to act as TRAIL-sensitizing agents.
aCSF in the same volume and on the same time schedule as TRAIL- or anti-TRAIL-treated animals.
Both urothelial carcinoma cell lines showed low sensitivity towards CD95L-induced as well as TRAIL-induced apoptosis.
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