Notably, RNase AS shows a mechanism of substrate recruitment, based on the recognition of the hydrogen bond donor NH2 group of adenine.
Our animal model for AS shows disease of the ankle and tarsal joints in the hind paws of mice.
Remarkably, however, the acetylated aS shows a distinct additional attenuation for the first 12 residues, followed by the transition to the characteristic flat profile for residues 25 90.
On the other hand, GHOST's AS shows superiority over MI-GRAAL's AS, as G-G consistently results in higher scores than G-M.
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