The NNRTI set represented a different data set compared to the GPCR ligand dataset evaluated above, as it consists of a number of highly similar sequences and compounds and, hence, resembles a typical data set one might encounter in lead optimization.
However, the decision to proceed or not with the surgical procedure relied only on pelvic examination and was based on whether there was or not response as evaluated with above described criteria.
These findings further corroborate the notion that loss of Mitostatin through mutations or protein degradation could contribute to prostate cancer progression insofar as the prostate cancer specimens evaluated above derive from advanced prostate cancer patients.
Gene Expression Analysis Enrichment of liver-specific genes in the proximity of highly conserved or human-specific promoters and enhancers was evaluated as above, using a combination of hypergeometric and Wilcoxon's tests.
The repeat lengths were manually evaluated, as stated above, as well as automatically evaluated by the GeneMapper Software v.4.0.
Parameters of angiogenesis were evaluated as above.
Eyelid closure was evaluated as above.
Values of D, D/Dmin and D* were evaluated as above.
For serial sphere assays, spheres were counted, collected by centrifugation, dissociated with trypsin, re-seeded and evaluated as above.
The method of randomization, allocation concealment, blinding, loss to follow-up, selective outcome reporting, trial funding, and if present other sources of bias were again independently evaluated arbitrated as above.
