Having established that AS contributes to the virulence of E. faecalis through our studies and those of others, we attempted to interfere with AS activity, and thus, possibly reduce the severity of endocarditis.
While it is acknowledged that AS contributes extensively to transcript and protein complexity and sophistication, it is still not often taken into consideration in functional studies of hematopoietic cells.
The progressive restriction in spinal mobility experienced by patients with AS contributes to significant functional disability and reduced HRQoL.
As a proof of this concept, aberrant regulation of AS contributes to the onset or progression of several human diseases, including cancer [ 19, 20].
The absolute numbers of confirmed AS per se are therefore not very indicative for the extent to which AS contributes to proteome diversity in A. thaliana.
Herein, we will discuss examples of how AS contributes to the enhanced adaptation capability of cancer cells towards the adverse conditions occurring during the tumorigenic process or triggered by therapeutic intervention.
