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But can you remotely claim that the things he did and the way he did them altered to any appreciable extent?
First, after intraventricular injection, rAAV1/2-based vectors were trapped in the ventricle wall and did not reach the parenchyma to an appreciable extent.
Continental collision involves the forced convergence of two buoyant plate margins that results in neither continent being subducted to any appreciable extent.
Suitable isotopes must have a stable or long-lived ground state and a low-lying excited state that decays to an appreciable extent by gamma-ray emission.
Enzymes are large protein molecules that act as biological catalysts, accelerating chemical reactions without being consumed to any appreciable extent themselves.
Indeed, it has offset to an appreciable extent the twin squeezes on economic demand of low wage rises and the austerity programmes favoured by Osborne and much of the eurozone.
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Because intracellular protein clearance mainly occurs via ubiquitin-dependent proteasomal degradation and given that intrinsically disordered proteins are not targeted by ubiquitination to an appreciable greater extent than ordered proteins (see section 3.3), this may constitute the most convincing argument for the comparable in vivo stabilities of both classes of proteins.
For example, the authors might consider to what extent cargo with appreciable cytoplasmic mass could fit into these tubular regions if they are coated with such a close-packed Sec23/24-Sar1 lattice.
Even more, as judged by the depth and extent of the scotomas, an appreciable functional deficit could be anticipated for at least some of these patients.
Pads of fat accumulation at waist had reverted to nearly normal appearance; the lumbar pad was no longer appreciable; breasts were still enlarged, although to a lesser extent (Fig. 1a).
While the enhancement of tensile strength by this extreme grain refinement can be quite appreciable, the fatigue strength is usually not improved to the same extent.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com