Exact(4)
Taken together, these findings reveal that overexpression of the transcriptional repressor Hbox12 in cells derived from the animal hemisphere impinges on the establishment of the DV axis.
10.7554/eLife.04664.011 Figure 5. Block of hbox12 function in the animal hemisphere of chimeric embryos, and effects on DV patterning.
Some manipulation experiments on the mouse zygotes, such as removing either animal or vegetal hemisphere region, suggest that localized factors at animal hemisphere direct the mitotic spindle and therefore define the plane of first cleavage [60].
These results support the contention that inhibition of hbox12 activity in the animal hemisphere, where it is normally expressed, is sufficient to impede the establishment of the DV axis.
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