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CCL and YSC analyzed the data.
YKC, SMS, and YSC undertook the statistical analysis.
GVA, CCHC, SH, UN, JK, BB and YSC contributed to acquisition and analysis of data.
YF and YSC evaluated sample quality control and performed the statistical analyses.
Critical revision of the manuscript for important intellectual content: CWP and YSC.
ICC, LCC and YSC designed this study; ICC, LCC, AKC, MC, HYH, CH and YL performed the experiments; NMT and KPC oversaw collection of clinical samples; CH evaluated human nasopharyngeal carcinoma tissue sections; YL supervised histological staining and analysis; ICC, LCC and YSC evaluated the data, and ICC, LCC, HPL and YSC wrote the manuscript; YSC and HPL supervised the project.
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KCB and YSC-C participated in the design of the study.
TW assisted with promoter analysis and YSC-C participated in the design of the study.
YSC and YJL conceived of and designed the study and were involved in the acquisition and interpretation of data.
For cryo-ET of the septin-Gic1 and septin-Gic1-Cdc42 complexes, 2 μM of YSC and 10 μM of Gic1 with or without 10 μM Cdc42-GppNHp were used, respectively.
Data were collected and analyzed by SC, ESK, SJK, HEY, CWP, YSC and SJS.
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