By wk 3 and wk 5 however, cortical volume decreases are widespread in the ipsilateral hemisphere.
Inoculations were performed at wk 0 (either 10 L3 or placebo) and wk 12 (either 5 L3 or placebo).
Additional lesioned animals, but not saline controls, sacrificed at wk 1 and wk 3 showed identical rotational behaviour (data not shown).
Lesioned animals showed a significantly shorter latency to fall compared to saline-controls at wk 1 (p<0.001), wk 3 (p<0.01) and wk 5 (p<0.01).
Fourteen of the 22 deaths occurred between wk 52 and wk 160.
Exercise levels were quantified at baseline and wk 12 using Godin's Leisure Score Index Questionnaire.
At baseline and wk 12, height, waist circumference and blood pressure were measured.
Serum concentrations of NEFA at wk -1 and wk +5 and of urea at wk +5 differed between health categories.
At baseline and wk 12, body composition was assessed with DXA (Hologic QDR 4500, Hologic, Inc., Bedford, MA).
All other placebo patients received ustekinumab 45 mg at wk 24 and wk 28, then q 12 wks.
At baseline and wk 12, a blood sample was collected in the morning after 12 hr of fasting.
