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THL and PJC performed the RAN and protoplast transactivation analyses, respectively.
JHM, CTY and PJC revised the manuscript.
B-RC, DCH and PJC carried out experiments.
CC, TFL, WLT and PJC: design and development of study.
The following authors were involved in study design: HHY, MKG, ABB, AAF, KMM, GL, XW, TCK, SJM, LRK, MP, and PJC.
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PJC and ART designed and performed research; PJC and ART analyzed data; PJC and ART wrote the paper.
The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of KL-6 concentration alone, and with PJC, were all 100% when the cut-off level of KL-6 concentration was from 32.7 to 39.4 U/mL for differentiating IPMC from IPMN.
SC- Supervised the field work and the statistical analysis; VCCD - carried out the laboratory work; AC, PJC and LCR - helped in the work design and reviewed the manuscript; MLB - coordinated the SCAALA project, helped in the work design.
Adding the KL-6 concentration of pancreatic juice to standard cytological assessment increased the sensitivity and accuracy of PJC by 15.3% (P = 0.025) and 8.5% (P = 0.048), respectively.
NP and JNO wrote the manuscript with critical evaluation by ID, PJC and PKC.
PJC and MT further contributed to the design and conduct of the study.
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CEO of Professional Science Editing for Scientists @ prosciediting.com