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This chapter discusses the characteristics of the JFET and CRD.
For the amplitude of DFT feature, two additional candidates CGD and CRD resulting in total ten candidates are considered.
KJS held the X-Ray diffraction research, determined cationic distribution of the samples and CRD of the samples, and conducted microstructure research.
The newly identified allergenic epitope of the Fel d 1 is useful in a design of the CRIT and CRD for cat allergy.
It is noted that CGD and CRD both model one-side distributions and are therefore proposed as candidates for modeling one-side distributed random vector, e.g., the amplitude of DFT feature.
Information on the antigenic repertoire, especially the IgE-binding epitopes of an allergen is important for understanding the allergen induced immune response and cross-reactivity, as well as for generating the hypoallergenic variants for specific component resolved immunotherapy/diagnosis (CRIT and CRD).
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We thank Gabriel Corfas for the Ig- and CRD-NRG1 HEK cells and Brian Howell for the reelin-secreting HEK cells; Mireille Rossel, Michael Davis, and Tom McFate for helpful comments; and Sarah Dhandu and LaToya Hyson for excellent care of the ferrets.
Two isoforms, Ig- and CRD-Nrg1, are expressed in sensory neurons (Meyer et al, 1997).
Furthermore, hypomyelination is observed in Bace1−/− and CRD-Nrg1+/− mice (Michailov et al, 2004; Willem et al, 2006).
The question arises of how Ig- and CRD-Nrg1 isoforms produced in the same sensory neurons exert their distinct roles.
Divergent intra- or intercellular trafficking mechanisms might exist that result in separate subcellular localization and function of Ig- and CRD-Nrg1 isoforms.
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