Neurotrophins were traditionally thought of as being produced by the targets of sensory neurons, but it became apparent from developmental studies that many sensory neurons can actually express and produce neurotrophins (Ernfors et al., 1990).
Yet, spinal motor neurons that undergo neurodegeneration, the pathogenic hallmark of ALS, actually express GluA3 and GluA4, in addition to GluA1 and GluA2.
Raving has allowed Gunn to "actually express myself and who I want to be," he said.
"But when we lose spaces where we can actually express ourselves and we can actually tell people about our experiences," he adds, "it's going to take us back to the old days where people were afraid to even speak out".
To verify that these ERα positive AVPV neurons actually express VGAT and VGLUT2 markers, we performed confocal microscopy on brain sections triple labeled for VGAT, VGLUT2 and ERα markers.
However, it is unclear which progenitors actually express Ngn1 and MiR-9 to affect a neuron-glial cell fate choice in vivo.
How many genes defined as 'pausing' genes actually express mRNA and how much mRNA from 'pausing' genes is transcribed is also still unclear.
In addition, neurons stain and can be shown to actually express the mRNA for a number of other secreted inflammatory proteins [ 37, 38].
In doing so a conception of responsibility as accountability restricts the way we can actually express our human agency and creativity, which is central to the approach based on phronesis, as we have noted in the previous section.
Though C-terminal RxRFamide peptides were initially considered as the protostome forms, oysters actually express both a NPF and two NPY peptides.
