Illumina, joined by some American scientists, said it worried that if BGI gained access to Complete's sequencing technology, the Chinese company might use low prices to undercut the American sequencing companies that now dominate the industry.
Shannon entropy analysis of the NS5 polymerase mature protein revealed that a G374E mutation, in a region that contributes to interferon resistance in other flaviviruses by interfering with JAK-STAT signaling was present in both the Asian and American sequences from the 2007 2008 Venezuelan outbreak, but was absent in the sequences from the 2001 Venezuelan outbreak.
She commends Bilheimer on alternating between American sequences and scenes in other countries, allowing "the experiences of young women with whom an American audience may more readily identify [to] become one among many woven into the fabric of global trafficking".
The non-Native American sequences likely introduced additional variation that artificially increased Ne prior to the expansion.
Our new analysis (with non-Native American sequences eliminated and more Native American sequences added) shows a larger population increase (80-fold vs 16-fold) over a smaller period of time (16 12 kya vs 16 9 kya) relative to our previous analysis that inadvertently included non-Native American sequences [1].
Specifically, they identified nine mitochondrial coding region sequences that we assumed were Native American sequences, but instead are likely to derive from Asian or European individuals.
It appears that the non-Native American sequences introduced additional variation that created an expansion signal that does not exist in an analysis of only Native American sequences.
The resulting tree (Figure S1) has a similar (though less well-resolved) topology, including the same clade of very similar, mostly North American sequences, with the remaining mostly-Eurasian sequences forming a weak group of long branches outside of the main Elymus clade.
This meta-analysis included sequences of genotype 1, but no South American sequences were considered.
In total, 35 variants in 46 African American sequences defined 27 different haplotypes.
