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Three amendments were implemented based on theoretical grounds and modification indices to improve model fit.
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Since the amendment was implemented in 1983, more than 150,000 women in Ireland have travelled abroad in order to have an abortion.
The citizen participation plan must provide a period, of not less than 30 calendar days, to receive comments on the consolidated plan substantial amendment or any revision to the AFH before the consolidated plan substantial amendment is implemented or the revised AFH is submitted to HUD for review.
If the amendment is implemented, agencies will be required to complete and post on their websites a disclosure form stating the compensation for each paid post.
This amendment was implemented in each region on different dates but was completed by September 2010.
Randomization to the TAC Elimination arm was stopped, patients up to 180 days after randomization were converted to standard treatment, those who were more than 180 days postrandomization could continue on their assigned regimen, and a protocol amendment was implemented.
In June 2008, therefore, a protocol amendment was implemented to widen the eligibility criteria to more pragmatically include patients assessed by their clinician to be at high risk of early breast cancer relapse irrespective of hormone receptor status.
A local protocol amendment was implemented at one site to allow optional collection of pre- and post-dose paired tumour biopsies at screening and at day 15 of BID dosing.
Due to the occurrence of two subjects with a glucose <2.2 mmol/L, an amendment was implemented partway into the study to manage more advanced hypoglycemia (<2.8 mmol/L) with a 50% reduction in TDD.
The primary reason for subjects not consenting to re-enroll for the extended follow-up was that they had already passed the 48-week timepoint when the protocol amendment was implemented.
Six months into the trial, blinded review of the pre-breakfast and pre-evening meal PG concentrations revealed that PG targets were not achieved in a substantial proportion of patients and a protocol amendment was implemented to ensure more frequent contact between patients and investigators during the last year of the trial.
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