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Exact(5)
Although elucidating this issue requires further investigation, our present data suggest that inhibiting upregulated expression or function of IRF8 may provide a way to comprehensively control the expression of a set of genes in reactive micro-glia.
Although elucidating the exact roles of these VviMAPKKK genes in pathogen interactions requires further functional analysis, our findings provide the first gene-family-wide survey on the expression patterns of specific grapevine MAPKKK in pathological conditions, and these highly up- and down-regulated genes can be candidate genes for future investigations.
Although elucidating the detailed biological roles of these targets will require further in-depth functional assays, it is likely that STAT6 also utilizes these previously poorly characterized transcripts in addition to canonical protein-coding transcripts for the fine tuning of target gene function.
Although elucidating the exact role of HSI2 will require additional research, available information indicates that it fulfils a negative role in maintaining physiological water potential under limiting water conditions and as such represents a potential target for genetic manipulation towards the development of crops better suited for cultivation under water-limited environments.
Taken together, these convergent lines of evidence strongly suggest a role for cuticular hydrocarbon variation in mate choice and speciation in the genus Timema, although elucidating the exact nature of this role will require additional studies.
Similar(55)
This highlights a novel function for BDNF in possible innervation in the degenerate IVD, although further work elucidating its exact role is necessary and should include investigation of BDNF-responsive nerves within the degenerate IVD.
However, although encouraging progress elucidating molecular mechanism on miRNA and HSCs has been achieved, there is a substantial need for more thorough investigations on how miRNAs are involved in HSCs development and tumor progression.
One point of consensus was that conditional alleles (i.e. cell-specific deletions created by cross-breeding of floxed Mecp2 mice with Credeleter lines), although useful for elucidating mechanisms of neurological dysfunction, are unlikely to be of value in translational studies because, by design, they do not recapitulate the global loss of MeCP2 that is characteristic of RTT.
Although Krebs elucidated most of the reactions in this pathway, there were some gaps in his design.
Such international discrepancies in influenza-related death rates have been highlighted on several occasions in the past, although not elucidated (18, 20 – 20 ).
Although we elucidated the mechanism underlying the rotenone-treated RPE cell death, it is not yet clear that this mechanism accurately describes the in vivo events pertaining to the therapeutics for PVR patients or the pathogenesis of AMD.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com