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Alternative translation initiation (ATI) generates two different protein products from a single transcript of TREK-1.
Alternative translation vectors need, therefore, to be chosen when one "moves up" in the mp → oc → hp hierarchy branch, see middle sketches in Fig. 1.
Alternative translation initiation is a common mechanism to generate protein isoforms.
Alternative translation initiation from a single mRNA may generate different C/EBPβ isoforms.
Alternative translation initiation of C/EBPβ isoforms can be shifted towards LAP expression by inhibition of mTOR signalling with rapamycin (Calkhoven et al, 2002; Jundt et al, 2005).
Calligaris, R., Bottardi, S., Cogoi, S., Apezteguia, I. & Santoro, C. Alternative translation initiation site usage results in two functionally distinct forms of the GATA-1 transcription factor.
Incomplete EEHV-gB amino acid sequences were produced from the plasmid presumably due to programmed ribosomal frameshifting (PRF) and alternative translation initiation sites.
6-Methyladenosine Guides mRNA Alternative Translation during Integrated Stress Response.
Recent evidence indicates that at least eight different GRα or GRβ N-terminal isoforms are generated from one single GR gene by alternative translation initiation [ 19].
This could indicate that some prokaryote genomes use alternative translation initiation processes to translate their genes.
We have reported that each GR transcript generates additional isoforms via alternative translation initiation mechanisms.
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