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It is likely that the LCR achieves this dual-gene activation function via dynamic and alternating interactions with the upstream and downstream genes.
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A binding association that is eliminated by ionic strength may be indicative of alternative MutL-ssDNA interaction(s) or alternate interactions in the presence of additional MMR proteins.
Although carboxylate containing compounds are likely to be prevalent among APE1 inhibitors, our screening results suggest that alternate interactions in the binding site may provide additional opportunities for the design of potent and selective endonuclease inhibitors.
These results in combination with our near-UV CD data indicate that pY-Vt and Y1065E cause some disruption in packing interactions likely due to alternate interactions of these negatively charged residues within Vt.
The model admits straightforward generalisation to other spatial dimensions, and alternate interaction topologies, but it is this original configuration that is used here.
This alternate interaction might account for the molecular basis of the functional redundancy and differences in NANOS2 and NANOS3 functions.
Its continuous structure does not allow distant, alternating vocal interactions.
How can a ribbon structure with alternating lateral interactions be formed during the assembly of tubulins?
At low temperature, the allosteric effect results in the observed sheet structure with alternating lateral interactions as the thermodynamically most stable form.
The turn-taking strategy resulted in alternating dominance interactions.
The particle surface charge was inverted during each layering step, indicating that the additional layer was constructed in a stepwise fashion followed by alternating electrostatic interactions.
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