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The study results showed that norfloxacin treatment, which was well tolerated and not associated with any serious systemic adverse effects, prevented acquisition of gram-negative bacillary organisms.
However, adverse effects prevented the patient from continuing with this regimen.
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Limitations of this study include the short duration of stable gabapentin treatment (8 weeks), which allowed only short-term assessments of safety and efficacy, and the exclusion of patients with PHN who had either previously not responded to gabapentin or pregabalin, or had dose-limiting adverse effects preventing titration of gabapentin to an effective dose.
However, serious adverse effects have prevented further development of therapeutic p38 inhibitors thus far.
26 Despite topiramate's proven efficacy, its high incidence of adverse effects has prevented its use as an obesity monotherapy.
Medication concerns might simply reflect actual adverse effects that prevent the regimen intensification required to improve outcomes.
While these hearing protectors provide increased safety in terms of auditory health, in some conditions they also have the adverse effect of preventing individuals from hearing alarm and warning signals which seriously compromises their safety.
Once diagnosed, however, adverse effects can be prevented by avoidance of fasting during episodes of catabolic stress.
The potential disadvantages of dexmedetomidine are hemodynamic changes, such as decrease in heart rate and/or increased or decreased blood pressure, but those adverse effects can be prevented by administering dexmedetomidine over 10 min.
Administration of amphotericin B is, however, associated with adverse effects that may prevent maintenance of effective doses [ 9].
Some suggest that government regulation may be needed to prevent adverse effects, as was done to prevent tobacco use by youth.
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