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Some of them have reached an advanced milestone in the pre-clinical investigation (Keppler et al, 1990; Sava et al, 1998a) and one, namely imidazolium trans-imidazoledimethylsulfoxidetetrachlororuthenate (NAMI-A) (Mestroni et al, 1998), is successfully completing a phase I clinical trial at the Netherlands Cancer Institute of Amsterdam (J Schellens, personal communication).
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Probability of achieving Preclinical Development milestone.
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CEO of Professional Science Editing for Scientists @ prosciediting.com