We thank Denis Timm for constructing the electric shock machine, Sailesh Varsani for help in administration of the experiments, Andreas Brogni for help in preparation of the physiological data, and Zuzanna Wojciechowska for supplying the voice recordings that were used for the Learner.
After final administration, results of the experiment were recorded using SMART 2.5.18 (Panlab S.L.U).
Animals were housed in the self-administration chamber during the self-administration phase of the experiment.
Furthermore, during the self-administration phase of the experiment, animals lived in the self-administration chamber, spending 18 hours of each training day not self-administering.
During the self-administration phase of the experiment, before the beginning of each daily self-administration session, a nonretractable response lever was mounted on a side wall of a standard operant chamber in which the animal lived.
One day following the cue-presentation test, animals were given access to cocaine using the same protocol as used during the self-administration phase of the experiment.
The described decrease in peak micturition pressure could also be attributed to the administration of furosemide during the experiment [ 12].
The patients with diabetes and strict administration of insulin during the experiment only marginally differed from healthy controls with respect to the plasma glucose concentration while their plasma insulin concentration was significantly higher.
Body weight of the eight rabbits in the topical experiment was 3 ± 0.3 kg; it was 3.1 ± 0.1 kg in the nine rabbits of the intravenous administration of JM-1232 experiment, and 3 ± 0.1 kg in twelve animals for the CO2 response experiment.
The intravenous administration of columbianadin experiment showed that the elimination of columbianadin was relatively quick and fitted with linear pharmacokinetics.
From the time-point of OA administration to the end of the experiment, the decline of MPsa (ΔMPsa) in group T was 42.6 ± 15.5 mmHg, which was significantly more than that of group C (9.4 ± 19.6 mmHg, p = 0.01) and group H (16.4 ± 15.4 mmHg, p = 0.034); however there was no significant difference in theΔMPsa between group C and group H (p = 0.491).
