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To do so, the city deftly adjusted testing procedures so that neither male nor female prospective firefighters, nor firefighters already on the force, challenged the procedures nor the outcome.
An alternative survival-adjusted test procedure based on isotonic regression methodology has previously been proposed.
Here, we introduce a new survival-adjusted test procedure that makes use of both the CA trend test and the isotonic regression-based trend test.
For the adult medication protocol, a sample size of 56 per arm (224 total) at the end of the washout was estimated to provide 80% power to detect a minimum effect size of 0.60 SD units between any two treatment groups in a baseline-adjusted ANCOVA when using a closed testing procedure to maintain an overall type 1 error probability α = 0.05 for either of the two primary outcome measurements (41).
Methods are provided for an adaptive closed testing procedure, for calculating overall adjusted p-values, and for obtaining unbiased estimators and confidence bounds for parameters that are invariant to modifications.
We rejected hypotheses based on adjusted p-values from the two-sample t-test using the Benjamini-Hochberg multiple testing procedure [ 19], as implemented in the multtest package in the statistical language R. R packages for use with cDNA microarray data are described in Dudoit et al. [ 20].
Fig. 10 Testing procedure details.
Figure 3 Robustness testing procedure.
The adjusted P-value for each comparison was computed using multiple testing procedures under free combinations (R package multcomp, option 'free' in the summary function).
Testing procedures are rigorous.
'Athletes have a right to expect fair testing procedures.
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