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Another important issue that needs to be addressed is clarification of the Ct-OATP1B3 function in cancer cells.
We contend that the alleged deficiencies claimed by Hoppe et al. [4] to undermine the conclusions of Pilling et al. [3] are incorrect, unjustified or are clear misunderstandings of the design, conduct and purpose of the original regulatory field studies, which could have been easily addressed by clarification with the authors.
All the comments can likely be addressed by clarification rather than any further experimental work.
The present results warrants further investigation addressing the clarification of the molecular mechanism determining this inverse correlation between sLex and E-cadherin as well as the investigation of the mechanisms by which sLex interferes with homotypic cellular adhesion mediated by E-cadherin in canine malignant mammary tumours, as a comparative model to woman breast cancer.
In this study, a novel stimulus responsive polymer (Jaber et al., 2011), partially benzylated poly allylamine), termed smart polymer E (SmP E) in this article, was investigated as a potential flocculant to address the mAb clarification and purification challenges discussed above.
Although the authors may have some of the additional requested data or be able to obtain them quickly and this might improve the manuscript, addressing the points that can be addressed through textual clarification should be sufficient for acceptance.
Once the press conference resumed, Blatter addressed calls for clarification regarding his resignation.
We also provided a telephone number and an e-mail address in case clarifications were desired.
We hope that the above clarifications address the general concerns of this reviewer.
After the FGD had begun, the facilitator asked questions only when a priority area of the topic guide was not being addressed or when clarification was needed.
The White House backpedaled last week and issued a clarification to address such concerns.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com