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If you want to take this route, please be sure to address all points, but importantly strengthen the modeling part with validation if at all possible.
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We hope you can address all the points and improve the text accordingly.
However, I hope you can satisfactorily address all the other points raised by the two referees with additional experiments where required.
Third, programs have often been rolled out individually to address specific barriers to demand, rather than forming part of a package of interventions that holistically address all the touch-points along the behavior change continuum for VMMC.
In the current manuscript, we addressed all the points by substantially revising the text as well as performing a series of new experiments.
One way to address all three points is a method in TDA called persistent homology (PH).
In any case, be sure to address all the points and questions raised in the application directions.
A scholarly discussion was added to the Discussion section, where we address all these points.
Although they did not address all the points mentioned, I think the current version is more consistent, and few vague comments have been modified.
We have revised the text in the Results and Discussion sections to further clarify the role GTP-hydrolysis to address all the points described above regarding the mechanism of the tubulin cofactors/Arl2 chaperone system.
From its beginnings with Snow and Whitehead, public health research has shown the need to address all possible points of water contamination, including sources and storage (Wright et al. 2004), sanitation systems (Cairncross 2003), and hygiene processes (Curtis et al. 2000; Curtis and Cairncross 2003).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com