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Additional substrates have now been identified, including the chondroitin-sulfate proteoglycans brevican and versican.
Additional substrates used throughout this study are described in Fig. 1.
Additional substrates of USP7 include claspin, FOXO4 and PTEN (Refs 40, 46, 47).
Here, we identify several additional substrates for uridylylation by poliovirus 3D polymerase.
The effect of the additional substrates placed in the cages was marginal.
Comprehensive motif-based searches and mutational analysis further established four additional substrates of SMYD2.
These pathways provided additional substrates and reducing power for ARA synthesis and ROS elimination.
In the first treatment, the periphyton biomass was increased using additional substrates placed in the cage.
In the second treatment, additional substrates were used and the diet was supplemented with a locally available compound feed.
Although not all of them have been confirmed as caspase targets, such proteomic approaches will certainly lead to the identification of numerous additional substrates in the near future (Table 1).
PKMTs are likely to have many additional substrates in addition to histones, but relatively few nonhistone substrates have been characterized, and the substrate specificity for many PKMTs has yet to be defined.
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