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Adaptive mutations that prevent crosstalk enable the expansion of paralogous signaling protein families.
Adaptive mutations are detected by linkage to the polymorphisms from the evolved parent.
Adaptive mutations in the JC virus protein capsid are associated with progressive multifocal leukoencephalopathy (PML).
Adaptive mutations have been mapped using bulk segregant analysis [59].
Adaptive mutations in mexA have been reported in CF isolates [ 7].
One student developed an algorithm to study adaptive mutations across the human genome.
Consequently, a selection of adaptive mutations that may account for the observed translation effects seems unlikely (Fig. 3d, e).
Tsetsarkin, K. A. & Weaver, S. C. Sequential adaptive mutations enhance efficient vector switching by Chikungunya virus and its epidemic emergence.
Taken together, the adaptive mutations detected in surface antigenic and bvg-controlled genes further emphasize the strong selective pressure on the B. pertussis genome due to herd immunity21.
Whole-genome duplication may allow duplicated genes to obtain new functions or adaptive mutations because the other copy retains the original function23,24.
A. M. Homes on writing novels, and on growing up in Washington, D.C. "All the markers of Wolfe's stylistic DNA were adaptive mutations to a competitive climate, search — engine optimization for the typewriter age".
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