Cancer immunotherapies aim to shift the balance back to dominant antitumor immunity through antibody blockade of immunosuppressive signaling pathways, vaccination, and adoptive transfer of activated or engineered T-cells.
Application of a magnetic field activated the engineered TRPV1 protein, as evidenced by transient increases in calcium ion concentration within the cells, which were detected with a fluorescence microscope.
Nanoliposomes and engineered carbon nanotubes can activate the complement system.
In this study, the collagen membrane was activated with the engineered human basic fibroblast growth factor (bFGF).
When the PKM gene was activated in the engineered flies 30 minutes after training, the flies had no trouble remembering the association the next day, the team reports in the April issue of Nature Neuroscience.
The maltose-dependent allosteric mechanism of RG13-AND2 cannot be fully activated until the engineered disulfide bond is reduced by changing the redox potential.
Once the nitric oxide signal was received, expression of a green fluorescence protein (GFP) reporter was activated in the engineered 'receiver' cells.
Strategies have included cell-based therapies such as transfer of ex vivo activated DCs or engineered T cells as well as antibody-based therapies that target specific T cell inhibitory pathways including CTLA-4 or PD-1/PD-L1 [ 3– 6].
Cell type-specific pharmacology for activating genetically engineered ion channels has been described (Slimko et al., 2002; Magnus et al., 2011), and here we demonstrate rapid cell type-specific blockade of a native ion channel with a small molecule.
Second, activating engineered protein switches that regulate cell morphology led to predictable changes in motility characteristics.
In contrast to conventional TCRs, CARs consist of a single chain and target exclusively cell surface antigens by an antibody-derived domain that is linked to one or more signaling molecules to activate engineered T cells.
