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An epithelial-to-mesenchymal transition (EMT) is thought to be an important process in the acquisition of capabilities required for metastasis.
The main obstacles in a case under scrutiny are related to insufficient funding, difficulties in the technology transfer processes, poor understanding of emerging markets and acquisition of capabilities needed in the form of competent management teams.
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This work will focus on the modeling of the evolutionary and developmental acquisition of linguistic capabilities based on the principles of symbol grounding.
an assessment of the role a partnership such as a partnership under the pilot project would play in the acquisition of cyberspace capabilities by the Department of Defense, including a role with respect to the development and approval of requirements, approval and oversight of acquiring capabilities, test and evaluation of new capabilities, and budgeting for new capabilities.
Cells lose adhesion with the loss of tight junctional proteins, like claudins, thus allowing the acquisition of migratory capabilities [44].
This latter process results from an epithelium to mesenchyme transition (EMT) [2], [3], characterized by loss of cell-cell contacts, loss of polarity and acquisition of migratory capabilities [4].
Since the ectopic clusters of electroporated cells remain close to the neural tube and no migrating electroporated cells are detected far away, it seems that ets-1 does not promote acquisition of migratory capabilities.
Genomic instability is a hallmark of cancer that leads to an increase in genetic alterations, thus enabling the acquisition of additional capabilities required for tumorigenesis and progression.
The dissemination of breast carcinoma cell outside the organ of origin involves multiple steps, e.g. loss or deregulation of normal cell-cell contacts, production of enzymes remodelling the extracellular matrix, production of motility factors and acquisition of migratory capabilities.
Malignant transformation is dependent on the acquisition of specific capabilities, from uncontrolled growth, to escape from apoptosis, to metastatic invasion (Hanahan and Weinberg, 2000), typically obtained through mutations or genomic rearrangements.
Cancer metastasis is considered to develop in a step-wise fashion leading to the acquisition of new capabilities by tumor cells helping them to thrive and evade natural barriers [ 3].
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