Sentence examples similar to Accumulation of mutations hypothesis from inspiring English sources

Accumulation of mutations was visualized using Circos [ 42 ].

Since the correlation between the HM profile divergence and the sequence divergence actually reflects the fundamental evolutionary process driven by the accumulation of mutations, we view this as a null hypothesis in the genome-wide functional analysis of duplicate genes.

There is a tremendous body of literature that supports the hypothesis that cancer results from the slow accumulation of mutations that eventually give rise to rare variant cells with metastatic potential.

The accumulation of mutations in certain cancers may reflect a mutator phenotype with globally random mutations [4] [6].

Arguably the most definitive validation of the somatic mutation hypothesis derives from the discovery that defective responses to DNA damage and the accumulation of mutations underlies two distinct types of hereditary cancer; skin cancer associated with defective NER and colorectal cancer associated with defective MMR11.

But the same reproductive check is not there to quell the accumulation of mutations interfering with fertility in middle age.

Genetic variation will only slowly be restored through the accumulation of mutations over many generations.

An accumulation of mutations, however, can lead to cancer," Shah explains.

Thousands of years of selection under cultivation have allowed for the accumulation of mutations that collectively comprise modern day germplasm.

While recombination can bring together multiple mutations within an organism, evolution in asexual populations depends on the sequential accumulation of mutations within a lineage.

Hence, the accumulation of mutations in the hydrophobic zipper has a gradual impact on the functionality of the PBP2 MreC complex.