While the original formulation of Green and Swets was designed only to account for the accuracy of choice data, a rich body of experimental and theoretical work subsequently extended the insights of signal detection theory into dynamical models in which evidence is accumulated gradually over time during single trials.
Cancer is driven by somatically acquired point mutations and chromosomal rearrangements, conventionally thought to accumulate gradually over time.
Cancer is known to be driven by somatically acquired point mutations and chromosomal rearrangements, conventionally thought to accumulate gradually over time.
The AluTa10 and AluTa15 subfamilies represent the first documented cases of a recently active 'fusion' element in which the diagnostic mutations were not accumulated gradually over time; instead, they represent the sudden incorporation of several signature mutations by way of a gene conversion event.
However, there are still ways to decipher some aspects of that early evolution, in particular, through detailed study of the numerous eukaryote-specific gene duplications [ 100] that, under the young LECA scenario, could have accumulated gradually over an extended period of time.
Hence, cancer initiation and progression are dependent on mutations and chromosomal rearrangements that can accumulate either gradually over time (gradualism) or in a single catastrophic event, such as chromothripsis (punctuated equilibrium) [ 34].
In agreement with our previous observation [29], we demonstrated that S6 phosphorylation, an event regulated by mTOR [53], [54], [55], is not simply sustained but is gradually accumulating over time following TCR triggering.
In contrast, under the DD condition, the fatty acid-derived volatiles gradually accumulated over time, but the terpene release was low.
In contrast to rabies virus, numerous SeV vRNPs appear throughout the cytoplasm during the early stages of infection and gradually accumulate over time.
Differences in characteristics such as forest dynamics, carbon storage, functional-guild composition, and species invasions could gradually accumulate over time, leaving an increasingly pervasive signature of divergence on community composition and functioning.
