It is reported that damage to the Na/K ATPase itself and/or subsequent impairment by the subnormal ATP production render neurons more sensitive to glutamate excitotoxicity [2], [17], [21], [22].
Independent of whether glycolytic insufficiency precedes or follows the process of T-cell aging, lower ability to generate ATP should render T cells sensitive to apoptosis and thus cause lymphopenia-induced T-cell turnover.
Moreover, deltamethrin has a general effect on the ATP concentration that renders dysfunction in normal physiological activities of fish (Kumar 2011).
In essence, during the ischaemic phase, blood flow and oxygen and nutrient supply to the organ are inhibited, which stops energetic metabolism, depletes ATP levels and renders the organ more susceptible to blood reflow in the reperfusion phase.
Indeed, K721A-EGFR, in which the lysine 721 to alanine mutation in the ATP-binding pocket renders the kinase dead55, is another example in which both aTKD and sTKD dimers form at the expense of oligomers (Fig. 7b).
Mitochondrial dysfunction has been implicated in the reduction of axonal ATP levels, thereby rendering the Na+, K+ -ATPase defective, compromising the ability for the axon to set up appropriate Na+ transmembrane gradients and inevitably initiating the axonal degenerative process [ 93].
In Cryptosporidium, the mitochondria have an altered ATP generation system that renders the parasite resistant to many classical mitochondrial inhibitors such as cyanide, azide, and atovaquone.
While the precise roles rendered by ATP and GTP binding/hydrolysis are unclear, cpHflX does not show a similar inhibition of GTP hydrolysis in presence of ATP [17].
Thus, one can speculate that GNF-2 introduces changes in the overall conformations of BCR/ABL-T315I, which renders the ATP-binding site more accessible to Dasatinib.
