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For 31 tumours, median (range) phosphomonoester (PME) to ATP ratio was 1.48 (0.57-3.78) and phosphodiester (PDE) to ATP ratio was 1.65 (0.44-3.89).
The fragility has the ATP/(ADP + ATP) ratio as its maximum value (hence the minimum robustness equals the (ADP + ATP /ATP ratio).
The AMP: ATP ratio is a key factor for AMPK to monitor energy.
While elevation of the AMP: ATP ratio promotes AMP binding to the γ subunit, which permits activation by LKB1, Ca2+ influx elicits activation by CaMKKβ independent of the AMP: ATP ratio [ 1- 3].
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Cardiac AMP-to-ATP ratio was significantly enhanced by ethanol exposure with a more pronounced increase in ADH mice.
A clue to the answer to this question is change in the phosphocreatine (PCr)/ATP ratio.
The phosphocreatine (PCr)/ATP ratio did not change following HIIT (p = 0.115; Table 2).
AMPK switches off ATP-consuming processes and switches on catabolic processes that produce ATP, thus restoring the AMP ATP ratio.
Any cellular stress that depletes cellular ATP and increases the ADP ATP ratio causes, via adenylate kinase, a much larger increase in the AMP ATP ratio.
Glucose deprivation induces a depletion of intracellular ATP [39], which consequently elevates the AMP ATP ratio and activates AMPK [29].
ADP and ATP levels were measured using an ADP/ATP ratio kit (Abcam).
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