Exact(43)
ATP citrate lyase catalyzes the formation of acetyl-CoA and oxaloacetate from cytosolic citrate and CoA in the presence of ATP.
ATP citrate lyase.
ATP citrate lyase (ACL) plays a critical role in generating cytosolic acetyl CoA, a key building block for de novo fatty acid and cholesterol biosynthesis.
ATP citrate lyase (ACL) shRNA lentiviral knockdown cells were used as a positive controls.
ATP citrate lyase (ACLY), a cytosolic gene important for the production of acetyl CoA was clearly downregulated.
ATP citrate lyase (ACL) connects glucose metabolism to lipid synthesis.
Similar(17)
The analysis suggested that the introduction of the ATP citrate-lyase reaction and the transhydrogenase reaction can improve the theoretical PHB carbon yield (Carlson et al. 2002).
When ATP is present, the enzyme ATP-citrate lyase (ACLY) in the cytosol converts citrate back to oxaloacetate and acetyl-CoA.
The fatty acid metabolism involves the ATP-citrate lyase (ACL), acetyl CoA carboxylase (ACC), fatty acid synthase (FAS) and palmitoyl-ACP thioesterase (PAT).
In order to convert accumulated citrate to cytosol acetyl-CoA, a heterologous ATP-citrate lyase (ACL) was overexpressed in yeast wild type and idh1,2 disrupted strains.
PFK 6-phosphofructokinase, GADPH glyceraldehyde-3-phosphate dehydrogenase, PGAM phosphoglycerate mutase, PK pyruvate kinase, ACS acetyl-coA synthetase, ADH alcohol dehydrogenase, ACO aconitase, IDH isocitrate dehydrogenase, SDH succinate dehydrogenase, ACL ATP-citrate lyase, NOX NADH/NADPH oxidase.
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