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First, previous studies on ATC used arbitrary wide bands.
Since the lower dose (10 mg/kg) of ATC used in this study was equivalent to the amount of ATC in the highest dose of HNK+ATC, which was used in humans, it is likely that the amount of AA-I human subjects received daily from this formula is conspicuously small.
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To characterize features of antithrombin concentrate (ATC) use in children receiving unfractionated heparin (UFH) therapy for acute thrombosis.
Although it might seem in contradiction with the ultrasensitivity of the input/output behavior (Hooshangi et al., 2005), it simply indicates that the aTc concentrations used for inducing the cascade are high enough to make the network insensitive to even large aTc variations.
Throughout the paper a concentration of 1.0 µg/ml anhydrous tetracycline (ATc) was used to induce the knock-out phenotype.
5'-tankyrase 1 cDNA PCR product (337-bp) was visualized when the primer pair (TNK1C632F: 5'-AGT CTT CTC CCC TGC ACT TC-3' and TNK1C969R: 5'-AGC TTT TGC TGA AGG ATC TG-3') was used.
ICD and ATC codes used in this study are detailed in online supplementary table S2.
12 Drug categories and ATC codes used are listed in web only table X.
bSee Additional file 1: Table S1 for anatomical therapeutic chemical (ATC) codes used to classify hypnotics.
ATC codes used were R05DA04 (codeine alone) and N02AA59 (codeine in a fixed combination with paracetamol).
The model, estimating the drug costs for every ATC class, used the official list prices of 2011.
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