Inflammatory bowel disease (IBD) is a well established example in that patients with IBD have an increased risk for the development of CRC [ 4].
Urea produced by reaction of CO2 and ammonia with a worldwide capacity of 108 tpa is the well established example of chemical utilization of CO2.
As in experimental fungal diseases there are a few but well established examples of antibodies whose protective value is modulated depending on the isotype [33], [38], we wondered whether, and to what extent, the anti-β-glucan IgM was also protective.
While there are many examples of HGT between prokaryotes [ 20], well established examples of HGT from prokaryotic into metazoan organisms are relatively few, with some examples revealed to be artifacts of improper analysis [ 13, 21- 23].
Well established examples of non-exponential population growth apply to global demography (super-exponential or hyperbolic case; q=2 [ 10]) and some molecular replicator systems (sub-exponential or parabolic case; q=1/2 [ 11]).
A well-established example of differentiation therapy is the use of all-trans retinoic acid in combination with chemotherapy in the treatment of acute promyelocytic leukemia [ 20].
A well-established example of this principle is the increased reduction potential of [2Fe 2S] clusters in Rieske proteins compared to ferredoxins due to replacement of two of the Cys ligands with His residues.
A well-established example of an sRNA-based dense overlapping regulon converging on one target in E. coli, is the co-ordinated regulatory control of the master regulator of the general stress response RpoS by ArcZ (originally named RyhA), RprA, DsrA and OxyS (Mandin and Gottesman 2010).
Ectopic bone formation is considered a good example for a well established theory in aging biology named antagonistic pleiotropy.
Comparing our transient assay system with VTG induction, a well established biomarker of oestrogen exposure, the detection threshold for EE2 (as an example) in zebrafish in vivo is 2 ng EE2/L [ 64].
SLC24A5 is a well-established example of recent local adaptation and is a major genetic factor that contributes to the light skin pigmentation in CEU (Lamason et al. 2005; Izagirre et al. 2006).
