Sentence examples for A substantial difficulty from inspiring English sources

In the present case a substantial difficulty arises from the fact that, beside imposing the volume constraint ({mathcal H}^n(Q(Gamma ))=omega _n) and that the barycenter of (Gamma ) is at the origin, we have also to fix some second order quantities.

The time points of all participant-related actions to be taken during the study period are presented in table 1. Retaining participants in a clinical trial of long-term duration represents a substantial difficulty for research teams.

The additional germ line cells occupy locations near somatic cells of interest throughout the trunk of the worm, which poses a substantial difficulty for annotation approaches that rely on location-based features alone.

For the higher dimensional situation, one can deal with it in a similar method without substantial difficulty.

A major drawback has been the substantial difficulty in designing HIF-specific inhibitors owing to the intracellular nature of the protein complex and the lack of active sites to which small molecular inhibitors are usually designed (Scheuermann et al., 2013).

In doing so we overcome a substantial theoretical difficulty in using reversible indel models during phylogenetic reconstruction.

While T. gondii has an intron rich genome and, consequently, presents substantial difficulty for gene prediction programs to properly identify gene coding regions, in C. parvum there are almost no introns and gene prediction is rather straightforward [ 20].

Subsequently, in response to strong appeals from the German government, the United States approved a similar arrangement between United and Lufthansa -- also at a time when the German carrier was in substantial difficulty.

We use some approaches to prove the global existence-boundedness of classical solutions and overcome the substantial difficulty of the existence of a nonlinear prey-taxis term.

It appears then that patients in stage 1 of the disease as a result of mild symptoms do not have substantial difficulty in their daily lives.

Participants in these focus groups felt themselves to be different from others, often from childhood, and reported that receiving a diagnosis of ADHD as adults can be accompanied by substantial difficulty.