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A substantial change in trial methodology for solid tumours has taken place, in response to increased understanding of cancer biology.
A substantial change in attitude is needed.
"It is a substantial change.
There are numerous options, most of which would entail a substantial change in working practices.
The end of Ramadan does not bring a substantial change in Tayyab's routine.
"This is a substantial change in the administration's commitment to Sierra Leone.
He has made, however, a substantial change in his method of composition.
In addition a substantial change in microstructure and texture of PRC Ni coatings was also evident.
Has the percentage of Indian students, and applicants, seen a substantial change in recent years?
If the second molecule is chemically different, there can be a substantial change in the luminescence.
It would be odd to make a substantial change today when we're on track.
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