However, with this in mind, it is important to note that the elucidation of a specific physiological role for a given glycan modification, such as sialylation, poses formidable challenge.
Since elucidation of a specific form of microsomal P450 exclusively associated with azoreduction remains elusive (Zbaida, 1995), we have shown that administration of DAB to mice, remarkably increases total P450 and that these changes are associated with hepatoxicity and lipid peroxidation, leading to the carcinogenesis onset.
Since the identification of polar toxicants is still one of the big bottlenecks of EDA; a specific focus is given to structure elucidation techniques using LC-MS/MS.
Sequencing of individual patient tumors has revolutionized oncology because the genetic information facilitates the elucidation of molecular changes in a specific patient's cancer.
The elucidation of novel regulatory motifs in the context of a specific cellular function may reveal new pathways and targetable mechanisms related to disease settings.
The elucidation of the effect that a single amino acid substitution (SAS) has in a specific phenotype is a central problem in different areas of research.
Their identification will therefore require a combination of approaches that include site-specific mutagenesis, elucidation of its crystal structure and a careful comparison with the known structure of the H. neapolitanus carboxysomal enzyme (PDB ID: 1SVD; Kerfeld, CA et al, 2005).
Our structural and in vitro interaction analyses provide a detailed elucidation of the specific recognition of FUNDC1 by LC3B and facilitate a deep understanding of how mitophagy receptors utilize the post-translational modification to sense environmental stress and elaborately regulate the selective mitophagy.
While each of these possibilities is reasonable based on the available data, the manuscript ultimately suffers from the lack of a clear elucidation of the specific contribution of VCP to maintenance of lysosome function.
Bayesian model selection based on non-linear ODEs has been shown to be a promising strategy for elucidation of specific signaling mechanisms (e.g. Xu et al., 2010).
Once the body of the report has included all relevant findings and observations, the radiologist must summarise in a conclusion, and this remains an art of distillation of what is important and an elucidation of what the specifics of the structured report mean.
