To visualize glucose uptake activity in live cells and tissues, we are performing SRS imaging on a novel glucose analogue labeled with a small alkyne moiety.
Based on molecular modeling analysis of the catalytic domain of OfHex2, a series of novel naphthalimide-scaffold conjugated with a small aromatic moiety by an alkylamine spacer linker were designed and evaluated as efficiently competitive inhibitors against OfHex2.
Modification of proteins can range from the addition of a small chemical moiety such as phosphate to the addition of peptides like ubiquitin and SUMO or the covalent cleavage of peptide backbone (1).
We cannot identify any smaller moiety than the atoms and bonds in a single reduced component.
These particles, although still observable, become less easy to isolate visually when moving towards a smaller ligand moiety on the left hand side of the figure.
In this work, a systematic investigation was performed on the binding behaviour of the model drug dexamethasone with βCD derivatives functionalized with a small, negatively charged moiety (carboxyl groups, CM) and a large, neutral, reactive moiety (hydrazide groups, Hzd), both free and grafted to dextran.
This review describes different strategies that have been used to promote substrate-mediated guidance of osteogenic differentiation of immature osteoblasts, osteoprogenitors and MSCs, through chemically conjugated small moieties, both in two- and three-dimensional set-ups.
Core histones can be methylated, phosphorylated, ubiquitinated and acetylated, to name just the best-known chemical groups involved, and these small moieties regulate the chromatin structure and subsequent gene expression.
In this reaction, glycan and protein are thus linked through a small fluorescent anthranilamide moiety.
SUMO is a small ubiquitin-like moiety that, when attached to protein substrates, regulates subcellular localization and activity [ 62, 63].
