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A significant issue for any would-be buyer is the status of Metro's London Underground distribution contract.
A significant issue for the application of numerical Landscape Evolution Models (LEMs) is their calibration/parameterisation and validation.
A significant issue for individuals exiting the prison system is how to overcome the structural deficits of stigma and discrimination associated with incarceration.
A significant issue for Brexit negotiations has been how to manage the border between the Republic of Ireland and Northern Ireland, which is part of the United Kingdom.
Falling participation figures have been a significant issue for golf.
ABC executives said the prime-time ratings are not a significant issue for late night ratings.
He voted for President Bush, partly because guns were a significant issue for him.
This is a significant issue for Yahoo, and it will likely be long term and durational.
"The shortage on the 5S was a significant issue for the quarter," Mr. Shammo told Reuters.
"I think that is a significant issue for people," he said.
It is also a significant issue for soldiers returning from combat.
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CEO of Professional Science Editing for Scientists @ prosciediting.com