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A significant breakthrough would require manpower the party does not have.
A significant breakthrough discovery was unearthed by the Linus Pauling Institute and Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, United States earlier this year.
A significant breakthrough was achieved when the study of membrane protein conformation became possible.
It was a significant breakthrough.
That would be a significant breakthrough.
In 2013 he made a significant breakthrough.
Within two years, he had made a significant breakthrough.
Nonetheless, Zostavax represents a significant breakthrough, several scientists said.
Coomaraswamy believes this week's ICC verdict is a significant breakthrough.
It is, though, a significant breakthrough for the women's game in England.
"It is a significant breakthrough that could only have been made on Beijing's initiative.
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